British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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Retrieved 8 December Originally released November 30, ; last updated April 23, ; expires April 23, Its original name reflects its origins as a compound secretly developed by British biochemists at Oxford University during World War II [13] [14] as an antidote for lewisitea now-obsolete arsenic -based chemical warfare agent. Chronicle of a Twentieth Century Medical Triumph.

More About Dimercaprol 1 reference found in Britannica articles Assorted References arsenic poisoning In arsenic poisoning. Nevertheless, BAL may still have some therapeutic value in patients who do not respond well to more modern agents Scheinberg and Sternlieb You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind.


BAL s use as the primary treatment for Wilson disease was short-lived because Walshe, inshowed the value of the less toxic chelating agent, penicillamine Walshe Skeletal formula and ball and stick model of dimercaprol. The Royal Society of Chemistry.

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British anti-Lewisite (dimercaprol): an amazing history.

From Wikipedia, the free encyclopedia. Dimercaprol is more effective if its use is begun within two hours after ingestion of the toxic metal.

The Editors of Encyclopaedia Britannica. Dimercaprol compound is useful for the treatment of potentially life-threatening acute arsenic poisoning as well.

In This Article Introduction. There was a problem with your submission. Archived PDF from the original on 13 December Arsenic poisoning Dimercaprol Succimer.

Television TVthe electronic delivery of moving images and sound from a source to a receiver. Lorincz of the University of Michigan has no relevant financial lewisute to disclose.

Dimercaprolalso called British anti-lewisite BALdrug that was originally developed to combat the effects of the blister gas lewisitewhich was used in chemical warfare.

British anti-Lewisite :: Development

InPorter found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson’s disease.


It was believed to have much greater toxicity than mustard gas, with some animal data suggesting that as little as one-third teaspoon on the skin would result in human death Vilensky Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs.

Pharmacy and pharmacology portal Medicine portal. This drug is not indicated in patients with iron, cadmium, selenium, silver, or uranium poisoning. During and after the war, nonmilitary uses for the heavy metal chelating action of BAL became apparent.

On first arrival in the United States ina series of studies was initiated to determine BAL lewisote biochemistry, pharmacology, experimental therapeutics, and clinical applications Waters and Stock Discover some of the most interesting and trending topics of Help us improve this article!

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